gobics.de [ Maike Tech ]

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• Colloquium
• Research
• Publications
• Software
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Teaching:

• Linux- und Perl-Praktikum für Biologen und Mediziner
  Linux-Skript (pdf, 485 kB)
• Bioinformatik-Praktikum für Fortgeschrittene
• Literaturseminar: Methoden der Bioinformatik
• Einführung in die Angewandte Bioinformatik

Research Interests:

• Metagenomics
• Gene prediction for prokaryotes
• Machine learning for pattern recognition in prokaryotic sequences
• Sequence analysis of fungal genomes

Software:

• Orphelia - Gene prediction in metagenomic sequencing reads
• TICO - Postprocessing of gene predictions for prokaryotes
• YACOP - Gene prediction tool for prokaryotes
• MrBayes - Easy to use webinterface to phylogeny program MrBayes

Publications:

• K. J. Hoff, T. Lingner, P. Meinicke, M. Tech (2009)
  Orphelia: predicting genes in metagenomic sequencing reads
  Nucleic Acids Research, Web server issue [pdf]
• K. J. Hoff, M. Tech, T. Lingner, R. Daniel, B. Morgenstern, P. Meinicke (2008)
  Gene prediction in metagenomic fragments: a large scale machine learning approach
  BMC Bioinformatics, 9:217
• M. Tech, B. Morgenstern, P. Meinicke (2006)
  TICO: a tool for postprocessing the predictions of prokaryotic translation initiation sites
  Nucleic Acids Res. Web Server issue, 34 [pdf].
• M. Tech and P. Meinicke (2006)
  An unsupervised classification scheme for improving predictions of prokaryotic TIS
  BMC Bioinformatics 7:121 [pdf].
• M. Tech, N. Pfeifer, B. Morgenstern and P. Meinicke (2005)
  TICO: a tool for improving predictions of prokaryotic translation initiation sites
  Bioinformatics, 21:17 [pdf].
• Talk at the Prokagen 2005, title: Prediction of Translation Initiation Sites in Prokaryotic Genomes with TICO [pdf]
• P. Meinicke, M. Tech, B. Morgenstern and R. Merkl (2004)
  Oligo Kernels for datamining on biological sequences: A case study on prokaryotic translation initiation sites
  BMC Bioinformatics 5:169 [pdf].
• M. Tech and R. Merkl (2003)
  YACOP: Enhanced Gene Prediction Obtained by a Combination of Existing Methods
  In Silico Biology 3:4.

Selected Posters

• K. J. Hoff, F. Schreiber, M. Tech, P. Meinicke
  The effect of sequencing errors on metagenomic gene prediction
  ISMB/ECCB 2009 [pdf]
• K. J. Hoff, M. Tech, P. Meinicke
  Predicting genes in metagenomic DNA fragments with high specificity using machine learning techniques
  ECCB 2008 [pdf]
• TICO poster at the GCB 2005 [pdf]

Theses

• Doctoral thesis (2007): Analyse von Translationsstarts in prokaryotischen Genomen mit Methoden des Maschinellen Lernens [pdf]; Title En: Analysis of translation initiation sites in prokaryotic genomes with machine learning methods
• Diploma thesis (2003): Vergleichende Untersuchung zur Verbesserung von Methoden der Genvorhersage [pdf]